Objective:To observe regulation of scorpio and scolopendra on intestinal mucosal immunity system in rats with collagen induced arthritis（CIA）.Method: Sixty rats were randomly divided into 6 groups:normal control group

model control group

low-dose Scorpio and Scolopendra group

middle-dose Scorpio and Scolopendra group

high-dose Scorpio and Scolopendra group

and typeⅡcollagen group.Rheumatoid arthritis was induced by Collagen.Level of lymphocyte subsets from peyer’s patches was measured by flow cytometry

and expression of TGF-β1

sIgA in intestine was detected by enzyme linked immunosorbent assay（ELISA）.Result: Cellular level of CD4+

CD8+ was obviously descending in all treated groups when compared with the model group（P<0.05 or P<0.01）.Except for middle-dose Scorpio and Scolopendra group

while expression of sIgA in enteric homogenate from other treated groups was notably heightened（P<0.01）.On the contrary

TGF-β1 was remarkably lower in middle-dose Scorpio and Scolopendra group and type Ⅱcollagen group（P<0.05 or P<0.01）.Conclusion: Regulation of Scorpio and Scolopendra on intestinal mucosal immunity system in rats with collagen induced arthritis was potentially implemented by regulating balance of T-lymphocyte subsets

down-regulating expression of TGF-β1 and increasing sIgA expression in intestine.