Objective:To investigate the effects of Taohong Siwu Decoction on myocardium interstitial collagen reconstitution in the non-infarction regions of left ventricle in rats after acute myocardial infarction.Method: Male Wistar SPF rats were used.The ventricle remodeling was induced by ligating the left main coronary artery.Ventricle remodeling rats were divided into 4 groups:Model group

Taohong Siwu Decoction group

captopril group

sham group（n=12

each）.Taohong Siwu Decoction group was orally given the decoction of 4.86 g·kg-1.Captopril group was given captopril suspension at 0.2 g·kg-1 with free drinking of water.Sham group and model control groups were given the same volume of drinking water.All the rats were continuously treated for 12 weeks.Afterwards

the rats were killed

the myocardial tissues were sampled and then pathologically observed through Masson trichrome staining.The proteins of myocardial tissue collagen Ⅰand collagen Ⅲ were determined through immunohistochemical methods.Result: Myocardial myofibril and myofilament in Taohong Siwu Decoction group were in good order

normal morphology

evenly and thinly distributed collagenous fibers

myocardial mesenchyme fibrosis obviously decreased compared with those in the model comparison group.The content of myocardium collagen and the ratio of myocardial collagen type Ⅰto Ⅲ collagen protein in model control group were obviously higher than that in the sham operation group.The content of myocardium collagen and the ratio of myocardial collagen type Ⅰto Ⅲ collagen protein in Taohong Siwu group and captopril group were lower than those in model control group.Conclusion: Taohong Siwu Decoction can inhibit proliferation of myocardium interstitial collagenous fibers and expression of collagen protein after acute myocardial infarction in rats

cut down the ratio of myocardial collagen type Ⅰto Ⅲ collagen protein in the non-infarction regions of left ventricle

relief collagen reconstitution.