WEI Jian-quan, LUO Ying, XUE Qiang, et al. Protective Effect of Kadsura heteroclite on Ethanol-induced Hepatotoxicity in Mice[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(13): 167-169.
WEI Jian-quan, LUO Ying, XUE Qiang, et al. Protective Effect of Kadsura heteroclite on Ethanol-induced Hepatotoxicity in Mice[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(13): 167-169. DOI: 10.13422/j.cnki.syfjx.2011.13.066.
Objective:To study the protective effect of Kadsura heteroclita(Roxb)Craib(KHC)on ethanol-induced hepatotoxicity in mice.Method: Mice were randomly divided into 5 groups to set up the model of hepatotoxicity by ethanol in mice:the normal
the ethanol model and 3 groups of KHC(33.40
16.70
8.35 g·kg-1).The activities of alanine transaminase(ALT)
aspartate transaminase(AST)
glutathione s-transferase(GST)
superoxide dismutase(SOD)in serum and the contents of malondialdehyde(MDA)
triglyceride(TG)in liver were measured.Result: KHC(33.40
16.70 g·kg-1
qd×7)could reverse the activities of serum ALT
AST
GST
SOD and could decrease the contents of MDA
TG in liver.Conclusion: KHC showed effective protection on ethanol-induced hepatotoxicity.