Objective:To explore whether there is the effect of Platycodon grandiflorum on the reduction of the acute toxicity of Crotonis Fructus

and the mechanism of this effect.Method: The death condition and LD50 were used to be the index to evaluate the toxic conditions in the compatibility Crotonis Fructus with different dosage of P.grandiflorum.Furthermore

we revealed the mechanism of toxicity reduction via determining the content of crotonoside in the compatibility Crotonis Fructus with different dosage of P.grandiflorum.Result: The toxicity of Crotonis Fructus was reduced after the compatibility of P.grandiflorum

especially when dosage ratio between Crotonis Fructus and P.grandiflorum is 1∶3

the degree of LD50 and the 95% confidence level elevation was biggest.Besides

after the compatibility of P.grandiflorum

the content of crotonoside was changed as parabola

which elevated firstly and reduced then.The result showed the content of crotonoside reduced 32.57%

with masimum degree

when the dosage ratio is 1∶3.Conclusion: 1∶3 of the dosage ratio is the best ratio for reducing the toxicity of Crotonis Fructus in the compatibility of P.grandiflorum.And the effect may relate to the reduction of free-state crotonoside.