Objective:To investigate the mechanism of Kangxian Yixin Formula（KXYXF）for inhibiting plasma aldosterone and angiotensin Ⅱin rats with dilated cardiomyopathy（DCM）.Method: Free drinking of furazolidone solution（700 mg furazolidone in 1kg of water）was used to establish DCM in rats.The rats were divided into model group

KXYXF high-dose group

KXYXF low-dose group

captopril control group.KXYXF combined with captopril group.The rats were accordingly treated daily with normal saline

KXYXF 18.8 g·kg-1

KXYXF 4.7 g·kg-1

captopril 10.125 mg·kg-1

KXYXF 18.8 g·kg-1combined with captopril 10.125 mg·kg-1ig for 8 weeks.Plasma angiotensin Ⅱ and aldosterone were determined by radioimmunoassay.Result: Aldosterone and plasma Ang Ⅱ were higher in the model group and compared with those in normal group[（159.94±12.03） vs（69.47±7.79） ng·L-1 and（1.23±0.09） vs（0.34±0.11） μg·L-1accordingly

both P<0.05].Compared with the model group

angiotensin Ⅱ and aldosterone in all treated groups（except KXYXF low dose group）were significantly decreased（P<0.05）;while the KXYXF high-dose group and the captopril group showed no significant difference（85.23±5.18） vs（87.90±6.02） ng·L-1 and（0.69±0.06） vs（0.74±0.42） μg·L-1 respectively).The KXYXF combined with captopril group showed statistically significant（P<0.05）

the KXYXF low dose group was also significant（P<0.05）.Conclusion: KXYXF can interfere with dilated left ventricular remodeling in rats with dilated cardiomyopathy（DCM）.This may be related to the inhibition of plasma angiotensin Ⅱ and aldosterone.