Objective:To observe the effect of Xingnaojing injection（XNJ）on malondial dehyde（MDA）

six-eight superoxide dismutase（SOD）

tumor necrosis factor-α（TNF-α）

interleukin-8（IL-8） in patients with acute brain injury

and investigate brain protective mechanism of XNJ.Method: 68 patients with severe craniocerebral injury were divided randomLy into experimental group and control group

34 cases in each group.Conventional therapy was used in control group.On the base of control group

30 mL XNJ with 5% glucose injection 500 mL were used in experimental group（once a day

10 days a course）.MDA

SOD

TNF-α

IL-8 were measured before therapy and after therapy.Result: Compared with that before therapy

Glasgow comascale（GCS） and SOD increased

MDA and TNF-α and IL-8 decreased significantly in experimental groups（P<0.05 or P<0.01）.Compared with that in control group

GCS and SOD increased

MDA

TNF-α and IL-8 decreased in experimental groups

there was a significant difference（P<0.05 or P<0.01）.Conclusion: XNJ can activate SOD

remove intracalvarium oxygen radicals

inhibit inflammatory factor such as TNF-α

and then improve consciousness of brain injury patients.