Drugs loaded in drug eluting stents（DESs） were introduced in this review.DESs have been dominant for the treatment of coronary artery disease in the interventional cardiology world owing to their preponderance in reducing restenosis.However

late in-stent thrombosis has become a major concern.Aiming to provide a clue for the design of future DES

this review focuses on the development of drugs（rapamycin

tacrolimus

everolimus

mytrolimus

taxinol） loaded in DESs and their roles in restenosis and thrombosis.Currently

there is insufficient information to evaluate the safety and efficacy of herbal medicine loaded in DESs for clinical use.Traditional Chinese Medicines（TCMs） have been extensively used to prevent and cure many diseases in China due to its low toxicity and rare complications.If herbal extracts（tetramethylpyrazine

emodin

curcumine

triptolide

puerarin

etc.） were loaded in DESs

the restenosis and thrombosis rate would decrease.