Insulin is an effective drug for diabetes mellitus in clinical practice

but the main administration is injection because of its quick degradation in gastrointestinal tract.To facilitate the use of insulin in clinical practice

the Non-injecting administration is investigated.In recent years

Non-injecting route of administration of insulin preparations has become a research hotspot.In recent years

better ways of insulin administration are being sought.Insulin has been rapidly developed in its non-injective delivery.Meanwhile

according to traditional Chinese medicine（TCM）theory

Chinese herbal medicine was effective in the treatment of diabetes.Traditional Chinese medicine combined insulin therapy can obtain better therapeutic effect.The recent developments for insulin administration and combination with TCM are reviewed and analyzed.