WANG Guang-ming1, PAN Yan2, KONG Qiu-ling2, et al. Observation on Bioavailability of α-Asarone by Its Inclusion Complex of Hydroxypropylcyclodextrins[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(15): 21-23.
WANG Guang-ming1, PAN Yan2, KONG Qiu-ling2, et al. Observation on Bioavailability of α-Asarone by Its Inclusion Complex of Hydroxypropylcyclodextrins[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(15): 21-23. DOI: 10.13422/j.cnki.syfjx.2011.15.019.
Objective:To observe the bioavailability of α-asarone by its inclusion complex of hydroxypropylcyclodextrins.Method:Rabbits were divided into two groups according to different solvents.The bioavailability of α-asarone was compared between the inclusion complex of hydroxypropylcyclodextrins group and water solution group in blood drug concentration
the content of ethmoidal concha
cerebral and olfactory brain.Result:The content of α-asarone in blood
olfactory brain
ethmoidal concha and cerebral has higher solubility in the inclusion complex of hydroxypropylcyclodextrins group than that in the water solution group.Conclusion:α-asarone has higher solubility in the inclusion complex of hydroxypropylcyclodextrins group than that in the water solution group.