Objective:To study the influence of Gualougen San on blood glucose and blood lipids in diabetic rats

analyse the relationship between hypoglycemic effect and drug dose.Method:SPF male Wistar rats were injected with 36 mg·kg-1 of STZ intraperitioneally to establish rat models of diabetes.According to the random number table

the model rats were randomly divided into the model group

the metformin hydrochloride group

the Ginseng-astragalus hypoglycemic granule group and the low

middle

high dose（2

4

6 g·kg-1） of Gualougen San groups（n=10 each）.Treatments were ig applied with corresponding drugs every day.Ten normal rats were set up as the normal control group（ig with normal saline）.The fasting blood glucose and weight of the rats were measured before the treatments and eight weeks after the treatments.Blood sample was finally obtained from aorta of rats.Triglyceride and cholesterol were tested.Result:High and low doses of Gualougen San could reduce blood sugar in the diabetic rats（P<0.01）.The low dose of the powder was the strongest while the middle dose of the powder did not show significant effect.High

middle and low doses of Gualougen San all could reduce blood lipids in the diabetic rats（P<0.05）

however

it could not control weight-losing in the rats（P<0.05）.Conclusion:Gualougen San can reduce blood sugar in type 2 diabetic rats without clear dose-effect relationship.The hypolipidemic effect is obvious while it can not change the trend of weight loss in diabetic rats.