Objective:To probe the mechanism of Honghua Ruyi Pill for treatment of chronic pelvic inflammation through observing inflammatory cytokine in serum and immune molecules relative to metrosynizesis.Method:The animal model of chronic pelvic inflammation was replicated by injection of phenol mucilage.After 10 days

the model was replicated successfully.The rats were divided into six groups randomly

normal group

model group

lower dosage of Honghua Ruyi Pill（0.156 g·kg-1）

middle dosage of Honghua Ruyi Pill group（0.469 g·kg-1）

large dosage of of Honghua Ruyi Pill group（1.407 g·kg-1）and Cinnamon twig and Poria capsule group（0.326 g·kg-1）.After the rats were treated 20 days with corresponding medicine by intragastric administration

the pathological of endometrium was observed and the concentrations of tumor necrosis factor（TNF-α）

interleukin-2（IL-2）and intercellular adhesion molecular（ICAM-1） were examined in serum by enzyme linked immunosorbent assay（ELISA）.Result:Honghua Ruyi Pill could alleviate obviously the pathological damage of endometrium.In comparison with normal group

serum IL-2 in model group was significantly decreased（P<0.01）

and TNF-α was significantly elevated（P<0.01）;the concentration of ICAM-1 in uterus was significantly elevated（P<0.01）.After Honghua Ruyi Pill（1.407 g·kg-1）treatment

serum IL-2 was obviously elevated compared with the model group and TNF-α was obviously decreased（P<0.05）;the concentration of ICAM-1 in uterus was significantly decreased（P<0.05）.Conclusion:Honghua Ruyi Pill can alleviate the inflammation and adhesion of pelvic by regulating the expression of inflammatory cytokines in serum and intercellular adhesion molecules in endometrium.