Objective:To investigate the effects of Naopingkang granule on learning and memory in rats after transient cerebral ischemia.Method:Sixty Wistar rats（n=10/group） were randomly divided into six groups:the normal goup

the model group

the Donepezil group

high Naopingkang granule group（12 g·kg-1）

middle Naopingkang granule group（6 g·kg-1） and low Naopingkang granule group（3 g·kg-1）.The treament groups were orally administered once per day separately

whereas the normal and model group were orally administered with distilled water.Ischemia model was made with 2-vessel-occlusion+hypotension

Morris water maze test and step-through passive avoidance test were employed to investigate the influences of Naopingkang granule on transient cerebral ischemia in rats.Result:In Morris water maze test

Naopingkang granule could significantly decrease escape latency time

swimming times in target quadrant was significantly recovered compared with that of model group（P<0.05）;in Step-through passive avoidance test

the shorter step-through latency and much error number induced in transient cerebral ischemia was significantly reversed by Naopingkang granule treatment compared with that of model group（P<0.05）;activety of AchE was inhibited compared with that of model group（P<0.05）.Conclusion:Naopingkang granule could improve learning and memory.