川芎嗪与葛根素配伍对脑缺血损伤大鼠脑组织内NGF水平的影响

朱慧渊

doi:10.13422/j.cnki.syfjx.2011.15.074

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川芎嗪与葛根素配伍对脑缺血损伤大鼠脑组织内NGF水平的影响

药理 | 更新时间：2024-09-23

- 川芎嗪与葛根素配伍对脑缺血损伤大鼠脑组织内NGF水平的影响
- Effects of the Combined Treatment of Ligustrazine with Puerarin on NGF Level in Rats with Cerebral Ischemia Injury
- 中国实验方剂学杂志 2011年17卷第15期页码：218-220
- 作者机构：
  
  陕西中医学院
- 作者简介：
- 基金信息：
  
  陕西省科技厅自然基金项目（20105Q4024）
- DOI：10.13422/j.cnki.syfjx.2011.15.074
  中图分类号： R285.5
- 纸质出版日期：2011
- 稿件说明：
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[1]朱慧渊.川芎嗪与葛根素配伍对脑缺血损伤大鼠脑组织内NGF水平的影响[J].中国实验方剂学杂志,2011,17(15):218-220.

ZHU Hui-yuan. Effects of the Combined Treatment of Ligustrazine with Puerarin on NGF Level in Rats with Cerebral Ischemia Injury[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(15): 218-220.
[1]朱慧渊.川芎嗪与葛根素配伍对脑缺血损伤大鼠脑组织内NGF水平的影响[J].中国实验方剂学杂志,2011,17(15):218-220. DOI： 10.13422/j.cnki.syfjx.2011.15.074.

ZHU Hui-yuan. Effects of the Combined Treatment of Ligustrazine with Puerarin on NGF Level in Rats with Cerebral Ischemia Injury[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(15): 218-220. DOI： 10.13422/j.cnki.syfjx.2011.15.074.

摘要

目的:探讨中药有效成分配伍对脑缺血损伤大鼠脑组织内神经生长因子（NGF）水平改变的影响。方法:将SD大鼠随机分为假手术组、模型组、川+葛（川芎嗪50 mg.kg-1+葛根素50 mg.kg-1）组、尼莫地平（0.5 mg.kg-1）组

采用改良的Pulsinelli四血管法制备脑缺血损伤动物模型

于再灌注0时、6时分组ip 1次。再灌注24 h后用免疫组织化学法测定NGF的水平。结果:模型组脑组织NGF含量较假手术组减少;川+葛组较模型组NGF含量增高

神经功能测定也有一定的提高。结论:川芎嗪与葛根素配伍对脑缺血损伤有一定改善作用

其作用机制可能与提高NGF含量有关。

Abstract

Objective:To determine the effects of combined treatment of ligustrazine with puerarin on nerve growth factor（NGF） level in rats with cerebral ischemia injury.Method:Rats were randomized into sham-operation group

model group

ligustrazine-puerarin group（50 mg·kg-1for both） and nimodipine group（0.5 mg·kg-1）.The four vessel occlusion method was used to establish the model.The level changes of NGF in brain and the changes of nerve function were investigated.Result:Compared with sham-operated group

in model group rats

the level of NGF in brain was decreased significantly;compared with model group the neuronal damage and inflammatory reactions were alleviated after the treatment

the content of NGF in brain was increased

and nerve function was improved.Conclusion:The combined treatment of ligustrazine with puerarin can prevent and cure the ischemia injury to some degrees.

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