Objective:To study the effect of Guanxin Danshen tablet on balloon catheter injury to common carotid artery of rat with hyperlipidemia.Method: For induction of hyperlipidemia

high fat emulsion was offered to rats by intragastric administration once a day for 30 d

after that

balloon catheter injury to the left common carotid artery was performed.after ballon injury

the high fat diet was continously given for 14 d.Meanwhile

the animals in diferent groups were accordingly given Guanxin Danshen tablet（0.72

0.36

0.18 g·kg-1）

simvastatin（4×10-3 g·kg-1） and normal saline（for model and sham-operated group） for 45 d.levels of cholesterol

triglyceride

high density lipoprotein

low density lipoprotein in serum were detected

Neointimal hyperplasia was observed by HE staining

and neointimal area

media tunica area and ratio of neointimal area/media tunica area were caculated.Result: Guanxin Danshen tablet could lower the cholesterol

triglyceride and low density lipoprotein in serum of rats with hyperlipidemia

reduce the area of neointiaml and diminish the ratio of neointimal area/media tunica area.Conclusion: Guanxin Danshen tablet could suppress the neointimal hyperplasia after ballon catheter injury to the common carotid artery of rat with hyperlipidemia.