LIU De-wen1, ZHANG Yi1, WANG Jin-yu1, et al. Tissue Distribution and Excretion of 8-Acetylharpagide in Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(23): 220-222.
LIU De-wen1, ZHANG Yi1, WANG Jin-yu1, et al. Tissue Distribution and Excretion of 8-Acetylharpagide in Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(23): 220-222. DOI: 10.13422/j.cnki.syfjx.2011.23.038.
Objective:To study on tissue distribution and metabolism of 8-acetylharpagide in rats.Method: The content of 8-acetylharpagide in tissue and excreta at different time points after tail vein injection were determined by HPLC
then analyzed distribution of 8-acetylharpagide.Result:After injected
the content of 8-acetylharpagide in heart
spleen
lung
kidney and uterus reached peak in 10 min
the highest concentration was in kidney;Concentration of 8-acetylharpagide in liver reached peak in 30 min
the content of 8-acetylharpagide in liver
lung and kidney reduced to a lower level in 60 min
it could not be detected in heart
spleen and uterus;after injected
8-acetylharpagide was discharged mostly through urine
less excreted by stool.Conclusion: By injection
8-acetylharpagide excreted in prototype drugs mainly.