Objective:To investigate the effect of Sini decoction（SND） on the intestinal mucosal injury and intestinal bacterial translocation induced by hemorrhagic shock.Method: The animals were randomly divided into normal group

shock model group

SND high dose group

SND low dose group.The shock model was induced by hemorrhaging for one hour and then resuscitating with shedding blood and same-volume Ringer lactate solution.The morphological changes in ileum mucosa were observed under light microscope.The intestinal bacteria in the liver

spleen

kidney and mesenteric lymph nodes was counted after 24 h culture.The level of endotoxin and D-lactate（D-Lac） in plasma was determined after 3 h resuscitation.Result: Compared with the model group

the intestinal pathology in SND groups significantly improved

the number of translocated intestinal bacteria and the level of endotoxin and D-Lac in SND groups were significantly reduced.The nitric oxide synthase（t-NOS） was significantly reduced and tumor necrosis factor-α（TNF-α） tended to decrease in SND group.The efficacy of SND was in a dose dependent manner.Conclusion: The SND can reduce intestinal injury and inhibit the translocation of intestinal bacteria.The mechanism may be related to inhibition of t-NOS

TNF-α.