Objective:To study the pathomorphological change of uterus in rats loaded by estradiol and progesterone and the interfering effects of Feke Zaizao pill（FKW）.Method: Sixty female SD rats were divided into 6 groups randomly:the normal group

the model group

the FKW low

moderate

high group（0.28

0.56

1.12 g·kg-1·d-1）

the Guizhi Fuling capsule group（0.3 g·kg-1·d-1）.The rats

except for the normal group

were injected with diethylstilbestrol and progesterone for eighteen weeks to establish uterine leiomyoma-like hyperplasia model.And from the end of the ninth week

FKW was used to interfering with the model rats by gastric perfusion.The uterus tissue was used to processing pathology detection by hematoxylin-eosin staining to observe the pathomorphological changes and the thickness of uterine smooth muscle to study the influence of FKW.Result: Compared with the normal group

the myometrium of rats in the model group incrassation obviously（P<0.01）

and the pathologic changes of uterus tissue of rats in the model group

such as smooth muscle fibre hypertrophy、irregular arrangement、interveined and the neutrophil infiltration in the uteri tissue

appeared significant differences which were analyzed by semiquantitative statistic analysis（P<0.01）.FKW could minish the degree of myometrium incrassation（P<0.05

P<0.01）

and improve the pathomorphological changes of uterus of model rats.Conclusion:FKW has the function of restraining and improving the uterine leiomyoma-like hyperplasia in rats

which could be produced by diethylstilbestrol and progesterone loaded.