XU Wei, SUN Wei-feng, LIANG Jing, et al. Effect of Psychological Stress on Gastric Emptying and Gastrointestinal Hormones and the Preventive Effects of Shengjiang Fang in Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(23): 171-173.
XU Wei, SUN Wei-feng, LIANG Jing, et al. Effect of Psychological Stress on Gastric Emptying and Gastrointestinal Hormones and the Preventive Effects of Shengjiang Fang in Rats[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(23): 171-173. DOI: 10.13422/j.cnki.syfjx.2011.23.071.
Objective:To study the effect of psychological stress on gastric emptying and gastrin(GAS)
motilin(MOT) in rats and the preventive effect of Shengjiang Fang.Method:Wistar rats were divided into 4 groups: control group
psychological stress group
psychological stress plus low dose of Shengjiang Fang 5.5 g·kg-1 and high-dose group(11.0 g·kg-1)
respectively.Gastric emptying ratios
GAS and MOT contents were measured.Result:Compared with the control group
the body weight
the gastric emptying ratio and GAS and MOT contents significantly decreased(P<0.01 or P<0.05) in psychological stress group.Compared with the psychological stress group
the body weight and the gastric emptying ratio and GAS and MOT contents both in psychological stress plus low and high-dose of Shengjiang Fang group were all increased(P<0.05).Conclusion:Psychological stress can decrease the gastric emptying rate and the GAS and MOT contents
Shengjiang Fang can antagonize the inhibitory effect of psychological stress on gastric emptying and increase the GAS and MOT contents in rats.