Objective:To evaluate Shuminfang influence on allergies and itching model.Method: The pharmacodynamic effects were observed in Passive cutaneous anaphylaxis by intravenous injection of Evans blue and subcutaneous injection of histamine phosphate

and itching model by intravenous injection of dextran in experimental animals.Result: Shuminfang high dose group can reduce the blue stained area of mice abdominal skin（P<0.05）

the inhibition rate was 73.85%

high and middle dose group can inhibit the skin vascular permeability induced by histamine phosphate（P<0.01）

the inhibition rates were 45.16%

41.94%;and can significantly reduce dextran-induced itching scratching number and shorten the duration（P<0.01）.Conclusion: Shuminfang has certain effect on skin allergies and itching.