Objective:To investigate the protective effect of Angong Niuhuang Wan on the cerebral ischemia and blood rheology in the rats.Method: Rats were randomly divided into sham group

vehicle group（normal saline was poured into the stomach at 12 mL·kg-1）

Angong Niuhuang Wan group（Angong Niuhuang Wan solution was at 0.25 g·kg-1）

Western medicine group（mannitol at 10 mL·kg-1 furosemide injection at 1.5 mg·kg-1 and citicoline sodium injection at 20 mg·kg-1 were determined tail vein injection）

integrated Chinese and Western medicine group.The model of focal cerebral ischemia of rat was established by the sutureoccluded method.Medications were administered after four days continuously of middle cerebral artery occlusion（MCAO） and stroke index evaluation was respectively studied at the first

second and third day after MCAO.By HE coloring

to observe the ischemic tissue after MCAO in four days later under the light microscope and examine the change of hemorheology.Result:After MCAO in four days the whole blood viscosity（ηb）

plasma viscosity（ηp）

platelet aggregation rate（PAgT） erythrocyte aggregation index（EAI）

erythrocyte rigidity index（IR） in vehicle group were much higher than those in sham group（P<0.05） and the DI in vehicle group was apparently lower than that in control group（P<0.05）;all the treatment groups could decrease the stroke index

the ηb

ηp

PagT

EAI and IR and increase the deformability index（DI） at different levels.Integrated traditional and Western medicine treatment showed more significant effect compared with other groups（P<0.05

P<0.01）.Conclusion: Angong Niuhuang Wan may protect brain from ischemia injury.The effect of Angong Niuhuang Wan might be related with improvement in hemorheological parameters.