Objective:To optimize extraction technology of Aikeqing capsule

a compound preparation of Chinese medicine.Method:Orthogonal test was used to evaluate extraction technology with yield of icariin

polydatin

glycyrrhizic acid and baicalin as indexes

optimum technology conditions were optimized by combined with comprehensive scoring method.Result:Optimum extraction conditions were as follows:H.Epimedii was heating refluxing extracted 2 times with 30 times the amount of 65% ethanol for 3 hours each time

extraction solution was concentrated in vacuum to relative density of 1.10（60 ℃）;then treated with 3 times the amount of 20% ethanol staying for 8 hours to filter off chlorophyll;extracted 3 times of mixed herbs powder of R.polygoni cuspidate

R.scutellaria

and R.glycyrrhizae with 10 times the amount of 80% ethanol for two hours each time.Conclusion:After tested by pilot

yield of maker compounds were 66%～88%

it showed optimized technology was feasible.