挤出滚圆法制备香青兰黄酮骨架型微丸

李悦; 邢建国; 杨秀; 王新春; 薛桂蓬

doi:10.13422/j.cnki.syfjx.2012.04.017

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挤出滚圆法制备香青兰黄酮骨架型微丸

工艺与制剂 | 更新时间：2024-09-23

- 挤出滚圆法制备香青兰黄酮骨架型微丸
- Preparation of Dracocephalum moldevica Flavonoids Skeleton-Type Pellets by Extrusion Spheronization Method
- 中国实验方剂学杂志 2012年18卷第4期页码：1-4
- 作者机构：
  
  1. 石河子大学药学院
  2. 新疆维吾尔自治区药物研究所
  3. 石河子大学医学院第一附属医院
- 作者简介：
- 基金信息：
  
  国家“十一五”科技支撑计划项目（2007BAI30B01）
- DOI：10.13422/j.cnki.syfjx.2012.04.017
  中图分类号： R283.6
- 纸质出版日期：2012
- 稿件说明：
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[1]李悦,邢建国,杨秀,王新春,薛桂蓬.挤出滚圆法制备香青兰黄酮骨架型微丸[J].中国实验方剂学杂志,2012,18(04):1-4.

LI Yue1, XING Jian-guo2, YANG Xiu1, et al. Preparation of Dracocephalum moldevica Flavonoids Skeleton-Type Pellets by Extrusion Spheronization Method[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(4): 1-4.
[1]李悦,邢建国,杨秀,王新春,薛桂蓬.挤出滚圆法制备香青兰黄酮骨架型微丸[J].中国实验方剂学杂志,2012,18(04):1-4. DOI： 10.13422/j.cnki.syfjx.2012.04.017.

LI Yue1, XING Jian-guo2, YANG Xiu1, et al. Preparation of Dracocephalum moldevica Flavonoids Skeleton-Type Pellets by Extrusion Spheronization Method[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(4): 1-4. DOI： 10.13422/j.cnki.syfjx.2012.04.017.

摘要

目的:优化挤出滚圆法制备维药香青兰黄酮骨架微丸的制备工艺。方法:用挤出滚圆法制备香青兰黄酮骨架微丸;采用单因素考察和正交设计筛选最优处方和工艺条件;考察微丸的粉体学性质和体外释放度。结果:采用挤出滚圆法制备的香青兰黄酮骨架微丸圆整度、流动性及堆密度均较好

成品收率高

且30 min内体外释放度均达到80%以上。结论:挤出滚圆法制备维药香青兰黄酮骨架微丸

工艺简便易行

制得的微丸质量好

收率高。

Abstract

Objective:To optimize preparation technology of Dracocephalum moldevica flavonoids skeleton-type pellets by extrusion spheronization method.Method:D.moldevica flavonoids skeleton-type pellets were prepared by extrusion spheronization method;Optimal formulation and process was obtained by single factor test and orthogonal design;Micromeritic properties and cumulative in vitro release of pellets were determined.Result:D.moldevica flavonoids skeleton-type pellets were prepared by extrusion spheronization method were all good of roundness

fluidity and density

product yield was high

in vitro release reached more than 80% in 30 min.Conclusion:D.moldevica flavonoids skeleton-type pellets were prepared by extrusion spheronization method

this preparation process was simple and feasible

quality of prepared pellets was excellent and product yield was high.

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