Objective:To study on optimum formulation and preparation technology of curcumol liposome by ethanol injection method.Method:curcumol liposome were prepared by ethanol injection method;taking entrapment efficiency and stability parameter as indexes

formulation and preparation technology were optimized by orthogonal test;entrapment efficiency of liposome was determined by HPLC.Result:Optimum formulation was:phospholipids 70 g·L-1

phospholipids-cholesterol 8∶1

pH of phosphate buffer 6.0

concentration of phosphate 0.10 mol·L-1;Optimum extraction technology was:probe ultrasonic time 4 min

magnetic stirring speed 30 r·min-1

water bath temperature 50 ℃

appearance of prepared curcumol liposome was uniform round

with entrapment efficiency was 62.91%

average particle size was 124 nm and average zeta-potential was-26.7 mV.Conclusion:preparation process of ethanol injection was simple and easy to control.optimized formulation and preparation of curcumol lipsome was stable and feasible.