Objective:A near-infrared（NIR） quantitative method was developed for rapid and nondestructive determination of moisture content in Danshen polyphenols acid injection.Method:The diffuse reflectance near-infrared spectra of Danshen polyphenols injection were measured intact by a fiber optic probe.The quantitative calibration model was developed using partial least squares（PLS） algorithm.Result:Using 53 samples Near-infrared spectra were pretreated with the second Derivative.The wavebands containing 11 993.1-6 098.8 cm-1 and 5 450.7-4 598.2 cm-1were selected

established and the quantitative calibration model of moisture content in Danshen polyphenols injection was established.The results shows that R2was 0.991 1

root mean square errors of Cross-Validation（RMSECV） was 0.210 and the best dimension was 4.10 samples as validation set

the RMSEP was 0.243.Conclusion:The presented method is timesaving

convenient and accuracy

which could be applied for rapidly determining moisture content in large numbers of samples.It is valuables for us to research the quality of traditional Chinese medical preparations.