Objective:To study on effect of borneol（natural or synthetic）

synthetic musk and total prescription of Xingnaojing on nasal absorption of gardenia extract.Method:After combined with different components

nasal absorption in rats of geniposide was investigated with modified in situ nasal perfusion model by volume correction method.Result:Absorption coefficients（K） of geniposide（the content of it were 36.8

92

368 mg·L-1

respectively） in gardenia extract solution（concentration were 100

250

1 000 mg·L-1） were（2.15 ± 0.70）×10-3

（1.97 ± 0.48）×10-3

（1.87 ± 0.81）×10-3 min-1

respectively.Nasal absorption of geniposide in gardenia extract fitted first-order rate process and could be considered as passive diffusion absorption.When gardenia extract combined with borneol（natural or synthetic）

synthetic musk and in total prescription of Xingnaojing

K value of geniposide was 1.4

1.7

1.1

1.3 times to it of gardenia extract alone

respectively.Correlation between in situ nasal absorption coefficients and in vitro mucosa permeability coefficients was good

KA=0.220 6 KI+0.559（r =0.991 0）.Conclusion:Nasal absorption of geniposide could be remarkably increased in Xingnaojing prescription and borneol played a major role in promoting absorption in this prescription.