Objective:To observe the protective effects of Shuangge Jiecheng Pill on ferments alcoholic fatty liver in rats.Method:The rat alcoholic fatty liver model was induced by 56%Hongxing wine by intragastric administration with 10 mL·kg-1

twice per day for 8 weeks.Then

the successfully modeled rats were successively administrated for 4 weeks

and randomly divided into model group

HW group（Haiwang Jinzun tablet

1.5 g·kg-1）and Shuangge Jiecheng pill（SG） group with high dose（HD）

middle dose（MD） and low dose（LD）（crude drug 20

10

5 g·kg-1·d-1）

and the control group was set up in the same period.After administration and fasting for 12 h later

the blood was obtained from arteria cruralis for detecting theactivity of γ-glutamy（transferaseγ-GT）

alanine aminotransferase（ALT） and aspartate aminotrans-ferase（AST）

and the liver index was observed also.Result:Compared with the control group

avtivity of γ-glutamyltransferase（γ-GT）

alanine aminotransferase（ALT） and aspartate aminotransferase（AST） and the liver indexes in the model group were obviously increased（P<0.05） while the body weight was decreased（P<0.01）.Compared with the model group

activity of γ-GT

ALT and AST and the liver indexes in the HW and SG group of HD

MD and LD were obviously decreased（P<0.05

P<0.01） while the body weight was increased（P<0.01）

and the indexes in SG group of HD were obviously decreased（P<0.05

P<0.01） than those of SG group of MD and LD.Conclusion:Shuangge Jiecheng Pill has an protective actions on for alcoholic fatty liver.