Objective:To study the effect of Jiangzhi granule（JZG） on hyperlipemia models.Method:Hyperlipemia models were established in mice

rat and quails.All animals were randomly divided into normal group

model group

xuezhikang group

JZG high

middle and low dose group.The dosage for mice

rat and quails was 10.0

5.0

2.5 g·kg-1

8.0

4.0

2.0 g·kg-1 and 8.0

4.0

2.0 g·kg-1

respectively Administration course was one week for mouse

four weeks for rats and 12 weeks for quails.The content of cholestero（CHO）

triglyceride（TG）

high density lipoprotein cholesterol（HDL-C） and low density lipoprotein cholesterd（LDL-C） in serum was determined after administration The atherosclerotic plaque in quail hyperlipemia models was exmined by histopathologic examination.Result:The content of CHO

TG

LDL-C in serum of mice

rats and quails was decreased remarkedly.The decrease of HDL-C/CHO index was reversed.Atheroselerotic plaque in quail lightened obviously.No change of HDL-C and VLDL-C were not found.Conclusion:JZG can effectively decrease the serum lipid and prevent the formation of atherosclerosis.