To analyze the reports on the relationships between tetramethylpyrazine（TMPZ） and the intracellular free calcium concentration under platelet activation

and to provide hint for further study of the pharmacological actions of TMPZ.By retrieving the following databases such CNKI

Wanfang

PubMed

and so on

to read relative publications.The current studies show that the intracellular calcium concentration in platelets increases due to platelet activation

which depends on the entry of calcium in the extracellular matrix and the release of calcium in endoplasmic reticulum.TMPZ plays its inhibitory role on platelet activation mainly through the suppression on the increase of the intracellular calcium concentration.It still remains unknown about the mechanism underlying the inhibition on platelet activation by TMPZ

and most of the studies suggest that TMPZ inhibits the intracellular free calcium concentration

leading to the suppression of platelet activation.However

those studies are much descriptive

instead of time-lapse observation on it.