Objective:To prepare tanshinone release pellets and research its preparation technology.Method:Tanshinone was prepared for release solid dispersion

influence of ethyl cellulose（EC） and hydroxypropyl methyl cellulose（HPMC） in different dosage on dissolution was investigated;Tanshinone solid dispersion as principal agent was prepared for pellets

effects of wetting agent

drug loading dose

accessories

lactose

wetting agent dose and other factors from prescription on yield and roundness of tanshinone were investigated;Optimum preparation technology of tanshinone release pellets was screened out by orhogonal design.Result:Tanshinone was prepared for release solid dispersion

prescription was tanshinone-EC-HPMC 1∶3∶0.5;Pellet was prepared by solid dispersion as principal agent

Formulation was tanshinone solid dispersion 20 g

lactose 6 g

MCC 24 g

33 mL water as wetting agent

optimum technology conditions were:extrusion frequency 25 Hz

rounded frequency 50 Hz

spheronization time 6 min.Conclusion:This process was scientific and rational

preparation was stable

it settled basis for preparation of multi-drug delivery system of Tongmai compound pellets.