Objective:To investigate the immunoregulation function of Erzhi pills and Dihuang decoction.Method: Female mice were adopted and divided into 6 groups: control group

model group

lentinan group（10 mg·kg-1）

group of Erzhi pills and Dihuang decoction（18.2 g·kg-1）

Erzhi pill group（7.8 g·kg-1） and Dihuang decoction group（10.4 g·kg-1）.Except for control group

mice in other groups were given cyclophosphamidum（CY） by intraperitoneal injection to establish immunosuppression model.Drugs were given intragastrically for one week in each group continuously according to respectively-designed doses.The thymus index

spleen index

level of serum interlukin-1α（IL-1α）

cellular cycle and apoptosis of spleen cells of mice were detected.Result: In model group

the thymus index（1.84±0.46）mg·g-1

spleen index（2.14±0.61）mg·g-1 and IL-1α level（135.21±28.69）ng·L-1 markedly decreased

proliferation of spleen cells were inhibited（2.37±3.08）% and their apoptosis rate was up to 52.86%

whereas the group of Erzhi pills and Dihuang decoction

Erzhi pill group

Dihuang decoction group and lentinan group could all increase the thymus index(group of Erzhi pills and Dihuang decoction（2.41±0.66） mg·g-1

Erzhi Pill group（2.57±0.62）mg·g-1

Dihuang decoction group（2.47±0.63） mg·g-1

spleen index(group of Erzhi pills and Dihuang decoction（5.17±1.58）

Erzhi Pill group:（4.40±0.87）

Dihuang decoction group（5.03±1.21） mg·g-1 and IL-1α level(group of Erzhi pills and Dihuang decoction（180.72±38.94） ng·L-1

Erzhi pill group（179.51±43.46）ng·L-1

Dihuang decoction group（172.93±40.91） ng·L-1 and resist the proliferation(group of Erzhi pills and Dihuang decoction（15.17±2.79）%

Erzhi pill group（9.55±3.73）%

Dihuang decoction group（10.86±4.29）% and apoptosis of spleen cells(group of Erzhi pills and Dihuang decoction（5.26±7.14）%

Erzhi Pill group（8.34±3.68）%

Dihuang decoction group（6.79±4.31）%caused by CY to varying degrees.Conclusion: Erzhi pills

Dihuang decoction and group of Erzhi pills and Dihuang decoction can enhance the immune function in immunosuppressed experimental animals and have the function of anti-apoptosis

in which the effect of Erzhi pills combined with Dihuang decoction is better than that of single one.