Objective:To evaluate the anti-inflammatory effects of the total saponins from Thladiantha dubia roots（RTDS）.Method: The effects of RTDS on acute and chronic inflammation were observed in the mouse nflammatory models of ear edema induced by dimethy benzene

paw swelling induced by carrageenan and granuloma induced by cotton pellet.Mice were divided into five groups

RTDS-high dose

middle dose and low dose（240

120

60 mg·kg-1）groups

aspirin（asp

100 mg·kg-1） group and the model group（saline）.Mice in ear edema and paw swelling model groups were administrated intragastrically for three days once a day.The models were established in 30 minutes after the last administration.The mice in granuloma model group induced by implantation of cotton pellet were administrated intragastrically for seven days.Result: The degree of ear edema in RTDS groups [（1.46±0.19）

（1.68±0.15）

（1.99±0.17） mg] was lower than that of the model group（2.31±0.24） mg（P

<

0.01）

the degree of paw swealing in RTDS groups [（28.7±5.03）

（33.8±4.65）

（43.33±4.98） mg] was also lower than that of model group（55.18±2.96） mg（P

<

0.01）

the granulomatous weight in RTDS groups [（5.08±0.37）

（6.76±0.44）

（8.66±0.55） mg] was lower than that of model group（12.05±1.22） mg（P

<

0.01）

and the effect of the high and（or medium） dose of RTDS was better than that of aspirin group（P

<

0.05

0

.01）.The prostaglandin E2（PGE2） absorbance value（0.193±0.022）

（0.219±0.035）

（0.250±0.037） and nitric oxide（NO） content（5.85±3.50）

（9.62±3.61）

（16.79±3.14） μmol·L-1 of serum in RTDS groups were lower than that of the model group（0.545±0.06）

（23.02±3.18）μmol·L-1)（P

<

0.01）.Conclusion: RTDS has significant anti-inflammatory effects

and this effect may be related to inhibiting synthesis and release of PGE2 and NO.