Objective:To study the effects of alcohol extracts from Bidens bipinnata L.on fasting blood glucose（FBG）

oral glucose tolerance（OGT） and index of thymus

spleen ofin diabetic mice induced by alloxan.Method:Diabetic mice were induced by intraperitioneal injection of alloxan and divided into different groups.The diabetic mice were treated with glibenclamide（25 mg·kg-1·d-1）

high-dose

mid-dose and low-doses of alcohol extracts of B.bipinnata（585

292

146 mg·kg-1·d-1） and normal saline

respectively

ig for 14 days.Meanwhile the levels of FBG were detected.After 30 min of administration on the day 14

the mice were administered glucose solution.The changes of glucose tolerance and the index of thymus

spleen were observed respectively.Result:The FBG level in diabetic mice treated by high-

mid-

low-doses of the alcoholic extracts of B.bipinnata was decreased significantly compared with model group

the FBG of high-

mid-

low-doses group was（19.88±9.26） mmol·L-1（P<0.01）

（21.68±6.17）mmol·L-1（P<0.05）

（22.05±11.02）mmol·L-1（P<0.05）respectively.The OGT enhanced at 0

0.5

1

2 h after giving glucose solution.The index of thymus

spleen was improved significantly compared with model group

the index of thymus（2.78±0.12）

（2.21±0.91）

（1.57±0.11）mg·g-1（P<0.05）

the index of spleen（4.61±0.37）

（3.31±0.62）

（3.25±0.36）mg·g-1（P<0.05）.Conclusion: The alcohol extracts of B.bipinnata have hypoglycemic effect in diabetic mice induced by alloxan.It also can improve the OGT and the index of thymus

spleen.