Objective:To investigate the effects of Puwei Pill（PWP） on expressions of vascular endothelial growth factor（VEGF） and basic fibroblast growth factor（bFGF） in gastric tissue in gastric ulcer recurrence rats.Method: The SD rats were randomly divided six groups: the normal control

the sham

the model without recurrence

the model with recurrence

the omeprazole and PWP groups.The chronic gastric ulcer model was built by using acetic acid.The rats in each group were administrated by ig at 24 h after modeling.The rats in the omeprazole group were ig given 3.6 mg·kg-1

once a day

the rats in the PWP group were ig given 40 mg·kg-1

once a week

and the rats in other groups were ig distilled water.To induce the gastric ulcer recurrence

the rats in other group except for the model without recurrence were ip given interleukin-1β（IL-1β） at 90 d after modeling.The recurrence rate was calculated at 48 h after inducing ulcer recurrence.The VEGF and bFGF in gastric tissue were determined by immunohistochemical staining and western blot methods.Result: The ulcers were not found in the normal control

the sham and the model without recurrence groups.The recurrence rate was 83.3% in the model recurrence group

but it was lower in PWP and omeprazole groups（P<0.01）

which was separately 11.1% and 33.3%.Compared with the model with recurrence group

the average positive dense of VEGF and bFGF was separately 127.03±13.47 and 122.40±23.17

and the average value of optical-density was separately 126.78±13.62

121.16±20.09

which was higher than in the normal control

the sham and the model without recurrence groups（P<0.01）

but was lower than in PWP and omeprazole groups（P<0.01）.Conclusion: PWP could decrease recurrence rate of gastric ulcer by increasing expression of VEGF and bFGF in gastric tissue.