Objective:To study the effect of Jianpi oral liquid（JPOL）on gastrointestinal motility

gastrointestinal hormones in mice with syndrome of spleen-deficiency to explore the mechanism.Method: Sixty mice were randomly divided into six groups: normal group

model group

low dose JPOL group

middle dose JPOL group

high dose JPOL group and positive control group（10 each group

including half male and half female）.The normal group and model group were given physiological saline of 15 mL·kg-1;while JPOL groups were administrated with JPOL at dose of 22.88

11.44

5.72 g·kg-1 respectively

and positive control group was given Qipi oral liquid（QPOL） of 8 mL·kg-1.Observation started from 14 days after modelling and administration of 7 successive days.Gastrointestinal motility

gastrins（GAS） and vasoactive intestinal peptide（VIP） in each group were observed.Result: Different doses of JPOL could improve the function of gastric emptying and inhabit small bowel peristalsis of mices to different extent.The different doses of JPOL could increase the content of GAS and decrease the content of VIP to different extent.Conclusion: The effect of JPOL may result from improving the function of gastric emptying

inhabiting small bowel peristalsis

the mechanism of which may be related to increasing the level of GAS and decreasing the level of VIP.