Objective:To study the effect of Danlou tablet on myocardial Infarct size and expression of Bcl-2 and Caspase-3 protein in rats with acute isoproterenol-induced myocardial infarction.Method:Forty male Wistar rats were randomly divided into 4 groups: Control group（normal saline 10 mL·kg-1·d-1

n=10）

model group（normal saline 10 mL·kg-1·d-1

n=10）

Danlou high dose group（900 mg·kg-1·d-1

n=10）

Danlou low dose group（450 mg·kg-1·d-1

n=10）.Each group was ig given for 14 d.Except for control group

the acute myocardial infarction model was induced by subcutaneous injection of Iso 15 mg·kg-1 in 14 d afte administration.The pathological changes in myocardial

myocardial infarct size and expression of myocardial Bcl-2

Caspase-3 protein were observed in 24 h after injection of Iso.Result: Compared with model group

Danlou tablet could significantly reduce the extent of ischemic myocardial injury

reduced myocardial infarct size（2.185±0.637）% vs（1.224±0.365）%

P<0.01)

Bcl-2 IA:（27.32 ± 7.00） vs（42.41 ± 8.13）

（P<0.01） protein expression was up-regulated

and Caspase-3 IA:（38.40±6.33） vs（26.26±6.79）

（P<0.01）protein expression was reduced

conclusion Danlou tablet can up-regulate Bcl-2 protein expression and reduce protein expression of Caspase-3

which may be related to protection against myocardial ischemic injury.