补肾填精方对再生障碍性贫血大鼠模型IL-11及EPO影响的研究

秦兰; 陈信义; 单丽娟; 谢荣

doi:10.13422/j.cnki.syfjx.2012.08.077

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补肾填精方对再生障碍性贫血大鼠模型IL-11及EPO影响的研究

药理 | 更新时间：2024-09-23

- 补肾填精方对再生障碍性贫血大鼠模型IL-11及EPO影响的研究
- Experimental Study on IL-11 and EPO in Aplastic Anemia Rat Treated with Tonifying Kidney and Replenishing Essence Prescription.
- 中国实验方剂学杂志 2012年18卷第8期页码：225-227
- 作者机构：
  
  1. 新疆医科大学附属中医院血液科
  2. 北京东直门医院血液科
  3. 新疆医科大学
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2012.08.077
  中图分类号： R285.5
- 纸质出版日期：2012
- 稿件说明：
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[1]秦兰,陈信义,单丽娟,谢荣.补肾填精方对再生障碍性贫血大鼠模型IL-11及EPO影响的研究[J].中国实验方剂学杂志,2012,18(08):225-227.

QIN Lan1, CHEN Xin-yi2, SHAN Li-juan3, et al. Experimental Study on IL-11 and EPO in Aplastic Anemia Rat Treated with Tonifying Kidney and Replenishing Essence Prescription.[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(8): 225-227.
[1]秦兰,陈信义,单丽娟,谢荣.补肾填精方对再生障碍性贫血大鼠模型IL-11及EPO影响的研究[J].中国实验方剂学杂志,2012,18(08):225-227. DOI： 10.13422/j.cnki.syfjx.2012.08.077.

QIN Lan1, CHEN Xin-yi2, SHAN Li-juan3, et al. Experimental Study on IL-11 and EPO in Aplastic Anemia Rat Treated with Tonifying Kidney and Replenishing Essence Prescription.[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(8): 225-227. DOI： 10.13422/j.cnki.syfjx.2012.08.077.

摘要

目的:观察补肾填精方对再生障碍性贫血（aplastic anemia

AA）模型大鼠调控因子白细胞介素-11（interleukin-11

IL-11）及红细胞生成素（erythropoietin

EPO）的影响。方法:Wistar大鼠随机分为空白对照组、模型生理盐水组、补肾填精中药组、再障生血片组共4组各12只

对照组正常饲喂不做干预;其他3组以5-氟尿嘧啶注射液（5-FU）与马利兰合用诱发建立模型后

补肾填精中药组及再障生血片组分别给予补肾填精中药10 g·kg-1及再障生血片混悬液0.015 g·kg-1

连续4周

模型组予等量生理盐水灌胃。结果:①治疗组的白细胞（WBC）、血红蛋白（Hb）、红细胞（RBC）及血小板（PLT）较模型组均有不同程度增高

差异有统计学意义（P<0.05）。其中补肾填精中药组的WBC和PLT明显升高

差异有统计学意义（P<0.01）。②治疗组IL-11含量较模型组升高

差异有统计学意义（P<0.05）。③治疗组EPO含量较模型组降低

差异有统计学意义（P<0.05）。结论:补肾填精方能改善模型大鼠的骨髓造血功能

可改善细胞因子IL-11及EPO介导的分泌异常

促进骨髓造血功能的恢复。

Abstract

Objective:To observed the effect of tonifying kidney and replenishing essence prescription（TKREP） on two regulation factors interleukin-11（IL-11） and eryhropictin（EPO） in Aplastic Anemia（AA） rats.Method: Forty eight clean grade Wistar rats were randomly divided into 4 groups

namely normal control group

AA model group

TKREP group and the aplastic blood-forming tablet（ABFT）group.The normal control group was fed with normal foods and vihicle.The other three groups were given the fluorouracil（5-FU） plus Myleran to induce AA model of rat.After that

the TKREP group and ABFT group rats were fed with TKREP（10 g·kg-1·d-1）and ABFT（0.015 g·kg-1·d-1） for 4 weeks.While

the AA model group was fed 0.9% NaCl.Result:①Compared to model group

the numbers of red blood cells and hemoglobin in treatment group were decreased

the difference was statistically significant（P<0.05）;the numbers of white blood cells and platelet in TKREP group were significantly decreased

the difference was statistically significant（P<0.01）;②EPO levels were elevated in treatment group

the difference was statistically significant（P<0.05）;③while the IL-11 level was increased slightly

the difference was statistically significant（P<0.05）.Conclusion: From point view of tonifying kidney

the TKREP could significantly improve bone marrow hematopoietic function against 5-FU plus Myleran

to a certain extent

effectively improve abnormal secreteing of regulation factors（IL-11 and EPO） and encouraged the bone marrow hematopoietic function’s recover.

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