Objective:To observe the histopathology effect of compound Danshen droppills on hepatic fibrosis in rats.Method: Wistar rats was injected 0.5% dimethylnitrosamine solution for 3 days

lasted for 4 weeks（2 mL·kg-1

once a day） to establish hepatic fibrosis model.The model was determined by biopsy and treated by Danshen droppills（292

146

73 mg·kg-1）through intragastric administration for 30 days.The histopathology of liver was observed and the size of hepatic fibrosis was calculated through IPP 5.0 soft ware.Result: After treatment for 4 weeks

the size of hepatic fibrosis in the 292

146

73 mg·kg-1 group was reduced（1 602±1 966）

（631±1 589）

（2 759±1 965）μm2 respectively

compared with model group

the three groups mentioned above had significant difference（P<0.01）.For the same group

there was no significant difference before and after treatment.Conclusion:The result showed that compound Danshen droppills has therapeutic effect on rat hepatic fibrosis.