Objective:To monitor changes in serum TNF-α

interleukin-4（IL-4） and interlukin-1β（IL-1β） in rabbit with acute pulmonary thromboembolism（APTE）

and to investigate the relation between inflammatory factors and lung injury.Method: Rabbit APTE model was established by auto-thrombus.The rabbits were randomly divided into control group and model group.ELISA was employed to determine serum TNF-α

IL-4 and IL-1β.Pathological analysis was carried out after the experimental operation.Result: In the early stage of APTE

there was no significant change in the parameters.After 6 h of thromboembolism

IL-4 was（42.8±1.35） ng·mL-1

whereas（16.9±1.59） ng·mL-1 in the controls（P<0.05）.After 4 h and 2 h of thromboembolism

TNF-α and IL-1β were（3.52±0.42） ng·mL-1 and（2.66±0.12） ng·mL-1accordingly

whereas（1.29±0.36） ng·mL-1（P<0.05） and（0.34±0.15） ng·mL-1（P<0.05） in the controls.Pathological evidence showed that arterial thrombus

lung tissue atrophy

bleeding and inflammatory responses were significant.Conclusion: The inflammatory factors induced by APTE play important role in acute pulmonary lung injury.