青蒿素自乳化制剂的设计、优化及质量评价

张小梅; 王云红; 杨荣平; 梁旭明; 林芳

doi:10.13422/j.cnki.syfjx.2012.09.009

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青蒿素自乳化制剂的设计、优化及质量评价

工艺与制剂 | 更新时间：2024-09-23

- 青蒿素自乳化制剂的设计、优化及质量评价
- Design,Optimization and Quality Evaluation of Artemisinin Self-emulsifying Preparation
- 中国实验方剂学杂志 2012年18卷第9期页码：59-63
- 作者机构：
  
  重庆市中药研究院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2012.09.009
  中图分类号： TQ461
- 纸质出版日期：2012
- 稿件说明：
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[1]张小梅,王云红,杨荣平,梁旭明,林芳.青蒿素自乳化制剂的设计、优化及质量评价[J].中国实验方剂学杂志,2012,18(09):59-63.

ZHANG Xiao-mei, WANG Yun-hong, YANG Rong-ping, et al. Design,Optimization and Quality Evaluation of Artemisinin Self-emulsifying Preparation[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(9): 59-63.
[1]张小梅,王云红,杨荣平,梁旭明,林芳.青蒿素自乳化制剂的设计、优化及质量评价[J].中国实验方剂学杂志,2012,18(09):59-63. DOI： 10.13422/j.cnki.syfjx.2012.09.009.

ZHANG Xiao-mei, WANG Yun-hong, YANG Rong-ping, et al. Design,Optimization and Quality Evaluation of Artemisinin Self-emulsifying Preparation[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(9): 59-63. DOI： 10.13422/j.cnki.syfjx.2012.09.009.

摘要

目的:设计并优化青蒿素自乳化制剂工艺

并对其进行体外质量评价。方法:通过测定青蒿素在不同油、表面活性剂、助表面活性剂中的溶解度

选择辅料。在三元相图的基础上

利用星点设计法优化青蒿素自乳化处方。以外观、溶解度、乳化时间、乳化后粒径和多分散系数为评价指标对青蒿素自乳化制剂进行质量评价。结果:青蒿素自乳化制剂最佳处方为中链甘油三酸酯-聚山梨醇酯-80-无水乙醇质量比31∶37∶20

外观透明均一

粒径234.7 nm

多分散系数0.235

溶解度2.775 g·L-1

乳化时间25 s。结论:青蒿素自乳化制剂工艺简单、性质稳定的

各项理化性质良好。

Abstract

Objective:To design and optimize technology of artemisinin self-emulsifying preparation

and evaluate its in vitro quality evaluation.Method:Excipients was selected by determining solubility of artemidinin in different oils

surfactants and co-surfactants.Based on ternary phase diagram

artemisinin self-emulsifying prescription was optimized by central composite design method.With appearance

solubility

emulsification time

particle size after emulsified and polydispersity coefficient as indexes to do quality evaluation of artemisinin emulsifying preparation.Result:Optimum prescription of this preparation was:MCT-tween-80-ethanol 31∶ 37∶ 20

it had uniform and transparent appearance

particle size was 234.7 nm

polydispersity coefficient 0.235

self-emulsifying time was 25 s

solubility was 2.775 g·L-1.Conclusion:Technology of arteannuin self-emulsifying preparation was simple and stable

it had good physical and chemical properties.

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