Objective: To explore and establish animal model of psoriasis combined with spleen deficiency syndrome.Method: Propranolol emulsion（5%） was used to establish psoriasis model.After the psoriasis model was successfully established

twenty-four guinea pigs were randomly divided in to two groups

psoriasis（group I

n=12） and psoriasis with spleen deficiency syndrome group（group II

n=12）.Another twelve guinea pigs were used as the blank control.For establishing spleen deficiency syndrome

group II was orally given bitter and cold purgative rhubarb twice（10 mL·kg-1） daily for a continuous duration of 7 d.Visual inspection and pathological section were carried out on ear skin lesions for all groups.Result: The total symptom scores of group II were higher than those in group I and the blank group

while the difference in Baker scores between the blank group and group I or group II appeared to be significant（P<0.05）.However

the Baker scores between group I and group II showed no statistical significance.Conclusion: The psoriasis model with spleen deficiency syndrome shows the pathological features of psoriasis

and with similarities of Traditional Chinese Medicine spleen deficiency syndrome.