Objective: To observe clinical effect of the combine Tongbi decoetion and western medicine treatment for ankylosing spondylitis.Method: Eighty cases of ankylosing spondylitis appeared within three months were randomly divided into two groups: 40 patients were treated by oral indomethacin enteric-coated metformin hydrochloride and ibuprofen as control group

the other 40 patients were treated by Tongbi decoction combine the above metioneal western medicine.Two groups of patients were treated for 3 months

and the therapeutic effect was evaluated.Result: In the observation group the total effective rate was 92.50%

and in the control group the total effective rate was 77.50%

with significant difference（P<0.05）.Before treatment two groups showed no differences in erythrocyte sedimentation rate（ESR）

creaction protein（CRP） and Immunog otulin A（IgA） after treatment

in the observation group ESR

CRP and IgA were（8.05±3.02） mm·h-1

（7.25±3.52）mg·L-1 and（1.58±0.87）mg·L-1

in control group ESR

CRP and IgA were（14.56±6.12） mm·h-1

（12.32±6.27）mg·L-1 and（3.02±0.89） mg·L-1

with significant difference（P<0.05）.Conclusion: Combine Tongbi decoction and western medicine treatment of ankylosing spondylitis could achieve benefical effect

and the approach is promising.