栀子提取物微丸的制备及其性质考察

吴黄焱; 倪健; 蔡程科; 何杨; 曲昌海; 尹兴斌

doi:10.13422/j.cnki.syfjx.2012.15.020

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栀子提取物微丸的制备及其性质考察

工艺与制剂 | 更新时间：2024-09-23

- 栀子提取物微丸的制备及其性质考察
- Preparation and Properties Investigation of Gardenia Extract Pellet by Extrusion-Spheronization Method
- 中国实验方剂学杂志 2012年18卷第15期页码：25-28
- 作者机构：
  
  北京中医药大学中药学院
- 作者简介：
- 基金信息：
  
  国家重大新药创制专项（2009ZX09502-008-3）
- DOI：10.13422/j.cnki.syfjx.2012.15.020
  中图分类号： R283;R286
- 纸质出版日期：2012
- 稿件说明：
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[1]吴黄焱,倪健,蔡程科,何杨,曲昌海,尹兴斌.栀子提取物微丸的制备及其性质考察[J].中国实验方剂学杂志,2012,18(15):25-28.

WU Huang-yan, NI Jian, CAI Cheng-ke, et al. Preparation and Properties Investigation of Gardenia Extract Pellet by Extrusion-Spheronization Method[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(15): 25-28.
[1]吴黄焱,倪健,蔡程科,何杨,曲昌海,尹兴斌.栀子提取物微丸的制备及其性质考察[J].中国实验方剂学杂志,2012,18(15):25-28. DOI： 10.13422/j.cnki.syfjx.2012.15.020.

WU Huang-yan, NI Jian, CAI Cheng-ke, et al. Preparation and Properties Investigation of Gardenia Extract Pellet by Extrusion-Spheronization Method[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(15): 25-28. DOI： 10.13422/j.cnki.syfjx.2012.15.020.

摘要

目的:优选栀子提取物微丸的处方工艺

并考察其粉体学性质和收率。方法:运用国产挤出滚圆机制备栀子提取物微丸;采用单因素试验优选微丸处方和制备工艺;评价微丸的粉体学性质和收率。结果:采用挤出滚圆法制备的栀子提取物微丸外形美观

圆整度好

大小均匀

成品收率高。结论:采用挤出滚圆法可制备性质优良的栀子提取物微丸

且快速稳定、可操作性好、工艺简单、成本低廉、节能环保

尤其适合于工业化大生产。

Abstract

Objective:To optimize prescription technology of gardenia extract pellet

and investigate its micromeritic properties.Method: Gardenia extract pellets were prepared by extrusion-spheronization equipment which was made in China

formulation and preparation process were obtained by single factor test

micromeritic properties of and yield of pellet were evaluated.Result: Gardenia extract pellets prepared by extrusion-sphemnization had beautiful appearance

good roundness

size uniformity and high yield of products.Conclusion: Extrusion-sphemnization method could prepared gardenia extract pellet with good nature

this method was rapid and stable with good maneuverability

simple process

low cost

energy saving and environmental protection

particularly suited for industrial large-scale production.

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