Objective: To observe the anti-inflammatory effects of Ephedra sinica-Glycyrrhiza uralensis herbal compatibility and explore its mechanism.Method: ICR mice were divided into 5 groups randomly

namely the model group

dexameathone group（0.01 g·kg-1）

E.sinica-G.uralensis herbal compatibility groups（22.4

11.2

5.6 g·kg-1）.Each drug was administrated to mice orally once a day for 5 days.After 30 min of the last administration

anti-inflammatory effect was observed by the method of acetic acid-induced permeability accentuation.SD rats were divided into 6 groups randomly

namely the control group

model group

dexameathone group（0.01 g·kg-1）

E.sinica-G.uralensis herbal compatibility groups（22.4

11.2

5.6 g·kg-1）.Each drug was administrated to mice orally once a day for 5 days.After 30 min of the last administration

the rat model of carrageenan-induced acute pleurisy was also selected to observe the anti-inflamatory activity.The anti-inflammatory mechanisms were investigated by detecting the contents of prostaglandins（PGE2）

tumor necrosis factor-alpha（TNF-α）

interleukin-lβ（IL-1β） in exudates

and the contents of TNF-α

IL-1β

malondialdehyde（MDA） in lung tissue were also detected.Result: Compared with the model group

E.sinica-G.uralensisherbal compatibility（22.4

11.2 g·kg-1）produced significant inhibitory effects on acetic acid-induced permeability accentuation in mice

and inhibited the increase of the volume of exudates（P<0.01）

as well as the total leukocytes in the exudates（P<0.01） induced by carrageenan

22.4 g·kg-1 inhibited the increase of the percentage of neutrophil

and three doses of herbal compatibility had no significant effects on the percentage of lymphocytes

E.sinica-G.uralensis drug pair（22.4

11.2 g·kg-1）significantly reduced the levels of PGE2

TNF-α

IL-1β in exudates（P<0.05）

drug pair 22.4 g·kg-1 also reduced the contents of TNF-α

IL-1β

MDA in lung tissue in carrageenan treated rats（P<0.01）

11.2 g·kg-1 reduced the contents of IL-1β in lung tissue（P<0.01）.Conclusion: E.sinica-G.uralensis herbal compatibility possess significant anti-inflammatory effects

which can be related with the inhibition of the generation of mediators of inflammation and its antioxidation.