Objective: To study the influence of the different ratio of cold-heat compatibility of Polyonum Cuspidatum（PC） and Ramulus Cinnamomi（RC） of Tongfengke in rat gout model.Method: SD rats were divided into normal group

the model group

PC-RC 3∶ 1（A group）

PC-RC 6∶ 1（B group） and（PC+SX）-RC 6∶ 1（C group） and positive medicine Colchicine group

the treatment groups were given corresponding drugs for 7 days.At 5th day using micro crystal uric acid sodium（MSU） method was used to reduce model

.After 2

6

8

12

24 h

of injecting MSU suspension the diameter and circumference of ankle joint were measured

and the foot swelling rate was calculated;serum uric acid and PGE2 level were determined two days after modeling The right rear ankle joint was collected to observe the ankle joint synovial organization and the pathological morphology change by light microscopy.Result: The foot swelling was inhibited

C formula at 24 h showed amarked inhibition（18.2%

P<0.05）;B

C formula could reduce serum uric acid levels（77.8 μmol·L-1 and 60.1 μmol·L-1

P<0.05）and PGE2 level（9.0 pg·L-1 and 9.1 pg·L-1

P<0.05） Inflammation change score could drop to 0.7;C formula showed a few inflammatory cell in synovial and soft tissue

the dilated small blood vessels were found;The actions of B and C grous were superior to other divisions.Conclusion: Cold-heat compatibility of Tongfengke with 6∶1 ratio is a good compatibility proportion;and can improve pathological changes.