Objective: To observe the protection of Shuxuening injection on myocardial ischemia induced by pituitrin in rats.Method: A myocardial ischemia model of rats was established by intravenous injection with pituitrin

through the electrocardiogram we could observe theⅡ electrocardiogram（ECG） ST segment

T wave and heart rate at different time points after inject pituitrin.The changes of the positive rate of myocardial ischemia and arrhythmia.Meanwhile we also observed the levels of serum superoxide dismutase（SOD）

lactate dehydrogenase（LDH）

malondialdehyde（MDA）

creatine kinase（CK） after 30 min and changes of myocardial infarct size and infarct rate.Result: Shuxuening injection could significantly improve the heart rate and electrocardiogram in acute myocardial ischemia induced by the pit

and reduce the positive rate of myocardial ischemia and arrhythmia.The content of LDH

CK

MDA was decreased

SOD activity was increased in serum and myocardial infarct size and infarct rates were reduced.Conclusion: Shuxuening injection has significant protective effect on acute myocardial ischemia induced by pit.