Objective: To study the effects of compoun Dcordyceps militaris（CCM） on immune function in C57BL/6 tumor bearing mice.Method: Transplanted Lewis tumor mice were established using subcutaneous injection of Lewis cells into C57BL/6 mice.C57BL/6 tumor bearing mice were randomly divided into five groups

namely

control group and positive group（cyclophosphamide ip 20 mg·kg-1）

the low

middle and high dosage groups（ig 1.2

2.5

7.5 g·kg-1） for 14 constitutive days.The tumor inhibition rate

CD4+/CD8+ ratio

contents of interleukin（IL）-2

IL-12 and tumor necrosis factor-α（TNF-α） in tumor bearing mice serum

antibody-producing cells and forced swimming time were respectively determined.Result: CCM（7.5 g·kg-1）

orally administered

had a significant inhibitory action on the growth of tumor

with the inhibition rate as 40.3%（P<0.05）.CCM（7.5 g·kg-1） also improved CD3+

CD4+

CD4+/CD8+ ratio compared with the control group.Meanwhile

CCM（2.5

7.5 g·kg-1） enhanced the content of IL-2

IL-12 and TNF-α level

forced swimming time and antibody-producing cells（P<0.05）.Conclusion: These findings suggested that CCM could promote the function of immunity in C57BL/6 tumor bearing mice.