Objective: To study the protection of compound recipe Hovenia dulcis powder and water extract groups on acute liver injury induced by carbon tetrachloride（CCl4） in rats.Method: Sixty male and female rats were devided into six groups randomly

the control group

the high-dose

middle-dose

low-dose of crude powder groups

the aqueous extract of H.dulcis group and model groups.The rats were injected carbon tetrachloride to copy the acute liver injury model

to observe activity of serum aspartate aminotransferase（AST）

alanine aminotransferase（ALT） and lactate dehydrogenase（LDH） after oral administrating compound recipe H.dulcis for 30 days.Result: Compared with model group and blank control group

ALT

AST and LDH levels were significantly increased.Compared with model groups in crude powder high-dose group

LDH were significantly improved.In the crude powder middle-dose group

ALT and LDH levels were significantly improved.In the crude powder low-dose group

ALT

AST and LDH levels were significantly improved.In the aqueous extract of H.dulcis group

ALT and LDH levels were significantly improved.The pathological change of liver was observed

compared with model and test groups

liver injury was alleviated by sum analysis of ranks

especially in the aqueous extract of H.dulcis group.Conclusion: Compound recipe H.dulcis shows protective effect against experimental liver injury in rats

especially the the aqueous extract of H.dulcis group has more significant action.