Objective: To study the effect of Fufang Danshen tablets and clopidogrel on the platelet activation in hyperlipidemic mice and its mechanism.Method: Fifty healthy Kunming mice were randomly divided into five groups: normal diet control group

high fat diet control group

clopidogrel gavage group

Fufang Danshen tablets gavage group and combined therapy gavage group.After administration of two weeks

the mice were killed and the blood samples were collected for the determination of serum total cholesterol（TC）

triglyceride（TG）

high-density lipoprotein cholesterol（HDL-C）

low-density lipoprotein cholesterol（LDL-C） and function of platelets.Result: Either clopidogrel or Fufang Danshen tablets had no effect on body weight in hyperlipidemic mice.Clopidogrel could significantly reduce the elevated TC and LDL-C of hyperlipidemic mice（P<0.05）.Fufang Danshen tablets could significantly reduce the elevated TC

TG and LDL-C in hyperlipidemic mice（P<0.05 or P<0.01）.The activated platelets ratio（45.75±6.94）% in hyperlipidemic mice was significantly higher than that in control group（28.02±5.86）%（P<0.01）.Clopidogrel could significantly reduce the elevated activated platelets ratio and neutrophil-platelet aggregation ratio in hyperlipidemic mice（P<0.01）.Fufang Danshen tablets could significantly increase the inhibitory effect of clopidogrel on the elevated activated platelets ratio

neutrophil-platelet aggregation ratio and monocyte-platelet aggregation ratio in hyperlipidemic mice（25.19%±4.16%） vs（32.48%±4.74%）

（8.64%±2.69%） vs（11.46%±2.33%）

（20.12%±4.65%） vs（24.74%±4.67%）

（P<0.01 or P<0.05）.Conclusion: The platelet in hyperlipidemic mice is highly activated.The comnined clopidogrel and Fufang Danshen tablets have synergistic effect.Fufang Danshen tablets can significantly enchance the inhibitory effect of clopidogrel on function of platelets in hyperlipidemic mice.