Objective:To investigate the recovering effect of Qizheng plaster on the bone defect in rat model.Method: The rat model of bone defect was established.Qizheng plaster was percutaneously given with doses of 2

1

0.5 g · kg-1 for 4 weeks.During the period

the effect was investigated by X-ray examination

serum calcium（Ca）

phosphorus（P） and alkaline phosphate（ALP） were measured

and biomechanical parameters were determined

and histopathologic examination was carried out.Result: In 2

1

0.5 g · kg-1 groups

the X-ray examination showed that of bone mineral density（BMD） in the bone defect parts was increased within 7-28 days.The gray value in the treated groups were higher than that of the model group

and had obvious difference on the 14th day（P<0.01）.There were no obvious changes in the serum ALP

Ca and P.Histopathologic examination showed that the generation rate of bony trabeculae and bony spicules in the 2

1

0.5 g · kg-1 groups were faster than that in the model group within 7-14 days.Conclusion: Qizheng plaster has recovering effect for the bone defect in rat model.