Objective:To observe the clinical influence of Tangshenan

a compound prescription of supplementing qi and nourishing yin and dispelling stasis to promote regeneration

on inflammation factors in diabetic nephropathy（DN）.Method:Forty-five DN patients were divided into treatment group（n=30） and control group（n=15） at random.And each of the two groups was treated with western medicine routinely

and the treatment group was combined with Tangshenan on this basis of western medicine.The two groups were both for a treatment course of 8 weeks.Then the variations of patients’ clinical responses

fasting blood glucose（FBG）

serum total cholesterol（TC）

Triglyceride（TG）

the inflammation factors of high-sensitivity c-reactive protein（hs-CRP）

tumor necrosis factor（TNF-α） and interleukin-6（IL-6）

were investigated.Result:After treatment

the total effectiveness of treatment group was 86.7%

and the control group was 53.3%

with significant difference（P<0.05）.For both the two teams

FBG

TC and TG were decreased significantly（P<0.05

P<0.01） after treatment.And the treatment group’s TC and TG’s decreasement was better than that in the control group.The treatment group’s Hs-CRP

IL-6 and TNF-α were decreased significantly（P<0.05

P<0.01） after treatment.The control group’s Hs-CRP level was also decreased significantly（P<0.01） after treatment

but the improvement of IL-6 and TNF-α were not obvious.Conclusion:On the basis of western medicine

if combined with Tangshenan

the curative effect can be improved

the blood lipid metabolism can be improved

and the regular inflammation factors can be down-regulated.